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Spike-triggered Analysis of Contrast Adaptation in the Retina
Liu, Jian; Movshon, Anthony (2013)
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clipboard		 Liu J., et al. "Spike-triggered Analysis of Contrast Adaptation in the Retina.", timms video, Universität Tübingen (2013): https://timms.uni-tuebingen.de:443/tp/UT_20130926_004_bestcon_0001. Accessed 09 Mar 2025.
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clipboard		 Liu, J. & Movshon, A. (2013). Spike-triggered Analysis of Contrast Adaptation in the Retina. timms video: Universität Tübingen. Retrieved March 09, 2025 from the World Wide Web https://timms.uni-tuebingen.de:443/tp/UT_20130926_004_bestcon_0001
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clipboard		 Liu, J. and Movshon, A. (2013). Spike-triggered Analysis of Contrast Adaptation in the Retina [Online video]. 26 September. Available at: https://timms.uni-tuebingen.de:443/tp/UT_20130926_004_bestcon_0001 (Accessed: 9 March 2025).
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title: Spike-triggered Analysis of Contrast Adaptation in the Retina
alt. title: Bernstein Conference 2013: Physiology of Vision
creators: Liu, Jian (author), Movshon, Anthony (annotator)
subjects: Bernstein Conference, Computational Neuroscience, Physiology of Vision, Spike-triggered Analysis, Contrast Adaptation, Retina, Jian Liu
description: Bernstein Conference 2013, 24. bis 27. September 2013
abstract: Retinal ganglion cells have to encode the visual world under different viewing conditions. When contrast changes, they show a fast dynamical change in sensitivity and temporal filtering characteristics. However, ganglion cells are often better described by multiple filter components in parallel. Here, we therefore ask whether these filter components adapt independently or whether the filters remain fixed, but their relative importance for the ganglion cell response changes. We thus study the temporal features represented in the ganglion cell responses by recording spikes from isolated axolotl retinas using a multielectrode array. We apply spike-triggered average (STA) and spike-triggered covariance (STC) analysis to determine the set of features represented by each ganglion cell under different contrast conditions. Following a switch from a low-contrast condition to one of high contrast, we found for OFF cells that the stimulus feature encoded by the STA under low contrast is preserved as the most significant feature detected by the STC analysis under high contrast. However, a second stimulus feature emerges as an additional filter component under high contrast. For ON-OFF cells with contributions from both ON and OFF pathways, on the other hand, this scheme does not hold. Rather, ON and OFF inputs are found to adapt independently. Further analysis of only those spikes that occurred in the OFF pathway recovered the observation made for pure OFF cells. A simple linear-nonlinear model with additional feedback can account for these filter changes during contrast adaptation. Together, these results suggest that contrast adaption occurs separately in ON and OFF pathways in the retina and can be described by changing the contributions from multiple parallel filtering processes.
publisher: ZDV Universität Tübingen
contributors: Bernstein Center for Computational Neuroscience Tübingen (BCCN) (producer), Bethge, Matthias (organizer), Wichmann, Felix (organizer), Lam, Judith (organizer), Macke, Jakob (organizer)
creation date: 2013-09-26
dc type: image
localtype: video
identifier: UT_20130926_004_bestcon_0001
language: eng
rights: Url: https://timmsstatic.uni-tuebingen.de/jtimms/TimmsDisclaimer.html?638770880923199207