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Multimodal integration allows the Mauthner cells to induce a fast escape
Hemmen, J. Leo van; Black, Michael (2013)
clipboard
mla
clipboard		 Hemmen J., et al. "Multimodal integration allows the Mauthner cells to induce a fast escape.", timms video, Universität Tübingen (2013): https://timms.uni-tuebingen.de:443/tp/UT_20130926_008_bestcon_0001. Accessed 29 Apr 2024.
apa
clipboard		 Hemmen, J. & Black, M. (2013). Multimodal integration allows the Mauthner cells to induce a fast escape. timms video: Universität Tübingen. Retrieved April 29, 2024 from the World Wide Web https://timms.uni-tuebingen.de:443/tp/UT_20130926_008_bestcon_0001
harvard
clipboard		 Hemmen, J. and Black, M. (2013). Multimodal integration allows the Mauthner cells to induce a fast escape [Online video]. 26 September. Available at: https://timms.uni-tuebingen.de:443/tp/UT_20130926_008_bestcon_0001 (Accessed: 29 April 2024).
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title: Multimodal integration allows the Mauthner cells to induce a fast escape
alt. title: Bernstein Conference 2013: Computational Vision
creators: Hemmen, J. Leo van (author), Black, Michael (annotator)
subjects: Bernstein Conference, Computational Neuroscience, Computational Vision, Multimodal Integration, Mauthner Cells, Fast Escape, J. Leo van Hemmen
description: Bernstein Conference 2013, 24. bis 27. September 2013
abstract: How to avoid a collision or, more usual in nature, an attack? And how to take the right decision to escape very fast? Multimodal integration of perceptive input is a key element of many behavioral decisions. For example, fish react with a fast (8-10 ms) directional escape response and, in doing so, need to detect the direction of an attack unambiguously. They manage this with high probability through a pair of brainstem neurons, the so-called Mauthner cells (M cells), which evolution has devised to induce the correct C-start. Extensive experimental research has shown that integration of acoustical-vestibular and lateral-line input is essential. Though the vestibular (saccule) input to both M cells is equal, because the pressure difference between both sides is not measurable, it is near the M-cell threshold. Conversely, the lateralline input is relatively low but has different arrival times at the left and right M cell whereas left and right lateral-line inputs differ to a large extent. We have developed a model of the two M cells (detailed compartmental modeling done with Neuron) with three synaptic-current inputs modeling the vestibular and the left and right lateral-line input from the posterior VIIIth nerve. Moreover, we have simulated PHP (passive hyperpolarizing potential) inhibitory interneurons, which ensure that only one M cell fires. This model shows that a fast and correct left-right discrimination is possible due to the multimodal integration performed by the M cells. We have studied the effects of changing duration and form of the inputs as well as the time difference between lateral-line input to the left and the right M cell and between the lateral-line and the vestibular input as well as changing duration and form of the inputs on directional discrimination. Furthermore, we have investigated the role of inhibition.
publisher: ZDV Universität Tübingen
contributors: Bernstein Center for Computational Neuroscience Tübingen (BCCN) (producer), Bethge, Matthias (organizer), Wichmann, Felix (organizer), Lam, Judith (organizer), Macke, Jakob (organizer)
creation date: 2013-09-26
dc type: image
localtype: video
identifier: UT_20130926_008_bestcon_0001
language: eng
rights: Url: https://timmsstatic.uni-tuebingen.de/jtimms/TimmsDisclaimer.html?638499489796445967