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Rapid developmental changes in the patterns of population activity accompany the onset of visual experience in ferret visual cortex
Fitzpatrick, David; Wolf, Fred (2013)
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mla
clipboard		 Fitzpatrick D., et al. "Rapid developmental changes in the patterns of population activity accompany the onset of visual experience in ferret visual cortex.", timms video, Universität Tübingen (2013): https://timms.uni-tuebingen.de:443/tp/UT_20130927_001_bestcon_0001. Accessed 23 Nov 2024.
apa
clipboard		 Fitzpatrick, D. & Wolf, F. (2013). Rapid developmental changes in the patterns of population activity accompany the onset of visual experience in ferret visual cortex. timms video: Universität Tübingen. Retrieved November 23, 2024 from the World Wide Web https://timms.uni-tuebingen.de:443/tp/UT_20130927_001_bestcon_0001
harvard
clipboard		 Fitzpatrick, D. and Wolf, F. (2013). Rapid developmental changes in the patterns of population activity accompany the onset of visual experience in ferret visual cortex [Online video]. 27 September. Available at: https://timms.uni-tuebingen.de:443/tp/UT_20130927_001_bestcon_0001 (Accessed: 23 November 2024).
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title: Rapid developmental changes in the patterns of population activity accompany the onset of visual experience in ferret visual cortex
alt. title: Bernstein Conference 2013: Cortical Dynamics and Circuits
creators: Fitzpatrick, David (author), Wolf, Fred (annotator)
subjects: Bernstein Conference, Computational Neuroscience, Cortical Dynamics and Circuits, Rapid Developmental Changes, Patterns of Population Activity, Onset of Visual Experience, Ferret Visual Cortex, David Fitzpatrick
description: Bernstein Conference 2013, 24. bis 27. September 2013
abstract: Early in postnatal development, at the time when experience begins to influence neural activity, visual cortex lacks the full complement of connections and the response selectivity that defines functional maturity. Studies in the ferret emphasize that visually-driven activity at this early stage is important for the construction of cortical circuits, especially those that represent stimulus motion. At the time of eye-opening, cortical neurons are weakly tuned to the direction of stimulus motion and they lack the columnar structure that characterizes the mature cortical representation. Both response selectivity and columnar structure for motion direction emerge during the first week to 10 days after eye-opening, in a process that is dependent on visual experience. The tuning of cortical responses for stimulus features is one measure of their functional maturity; But this measure does not assess the spatio-temporal dynamics of cortical activity that are supported by immature circuits and how these activity patterns change in response to visual experience. In vivo imaging of calcium signals using genetically encoded calcium sensors reveals that the emergence of direction selectivity after eye opening is accompanied by dramatic changes in the dynamics of population response of layer 2/3 neurons. Initially, visually driven responses are highly variable yet show strong correlations across the population, and frequently exhibit slow wave-like dynamics. Stimulus induced responses are orientation tuned, and they form well-defined patches which exhibit complex wave trajectories. Combined cell attached recordings and 2-photon imaging confirm that these early calcium signals are correlated with the spiking activity of layer 2/3 neurons. With visual experience, responses become more reliable, less correlated, and the wave-like activity disappears. Several lines of evidence show that these changes in responsiveness are accompanied by significant changes in cortical inhibition. The density of parvalbumin immunoreactive GABAergic terminals in ferret visual cortex undergoes a striking increase in the first week after eye opening and there is an equally strong increase in the frequency of spontaneous inhibitory synaptic currents. Taken together, these results suggest that the maturation of cortical direction selectivity may depend on changes in inhibitory circuits that shape the spatiotemporal structure of cortical responses.
publisher: ZDV Universität Tübingen
contributors: Bernstein Center for Computational Neuroscience Tübingen (BCCN) (producer), Bethge, Matthias (organizer), Wichmann, Felix (organizer), Lam, Judith (organizer), Macke, Jakob (organizer)
creation date: 2013-09-27
dc type: image
localtype: video
identifier: UT_20130927_001_bestcon_0001
language: eng
rights: Url: https://timmsstatic.uni-tuebingen.de/jtimms/TimmsDisclaimer.html?638679603833306727