Diese Anwendung erfordert Java-Skript.

Bitte aktivieren Sie Java-Script in den Browser-Einstellungen.
Structural Determinants of Spatial Representations in Layer 2 of Medial Entorhinal Cortex
Burgalossi, Andrea; Wolf, Fred (2013)
clipboard
mla
clipboard		 Burgalossi A., et al. "Structural Determinants of Spatial Representations in Layer 2 of Medial Entorhinal Cortex.", timms video, Universität Tübingen (2013): https://timms.uni-tuebingen.de:443/tp/UT_20130927_004_bestcon_0001. Accessed 29 Apr 2024.
apa
clipboard		 Burgalossi, A. & Wolf, F. (2013). Structural Determinants of Spatial Representations in Layer 2 of Medial Entorhinal Cortex. timms video: Universität Tübingen. Retrieved April 29, 2024 from the World Wide Web https://timms.uni-tuebingen.de:443/tp/UT_20130927_004_bestcon_0001
harvard
clipboard		 Burgalossi, A. and Wolf, F. (2013). Structural Determinants of Spatial Representations in Layer 2 of Medial Entorhinal Cortex [Online video]. 27 September. Available at: https://timms.uni-tuebingen.de:443/tp/UT_20130927_004_bestcon_0001 (Accessed: 29 April 2024).
file download bibtex   endnote
Information
title: Structural Determinants of Spatial Representations in Layer 2 of Medial Entorhinal Cortex
alt. title: Bernstein Conference 2013: Cortical Dynamics and Circuits
creators: Burgalossi, Andrea (author), Wolf, Fred (annotator)
subjects: Bernstein Conference, Computational Neuroscience, Cortical Dynamics and Circuits, Structural Determinants, Spatial Representations, Layer 2, Medial Entorhinal Cortex, Andrea Burgalossi
description: Bernstein Conference 2013, 24. bis 27. September 2013
abstract: Medial Entorhinal Cortex (MEC) is a key structure contributing to spatial information processing. In superficial layers of MEC, extracellular recordings show spatial discharge patterns such as grid, head-direction and border cells, which may help generating a cognitive map of the environment. A subset of pyramidal principal neurons in L2 MEC with calbindin immunoreactivity (Cb+) is clustered in patches and is-as we recently observed-arranged in a hexagonal pattern. These pyramidal neurons receive selective cholinergic innervation and earlier work has shown that these pyramidal cells differ in intrinsic properties and projection patterns from L2 stellate cells. These findings made us wonder how the unique physiology and anatomy of calbindin positive pyramidal cells and stellate cells relate to the functional diversity in L2 MEC neurons. To address this question, we optimized our juxtacellular recording technique in freely moving rats trained to explore open-field environments. This technique enables us to record and label multiple cells per animal, which were classified by Cb immunofluorescence. Preliminary results show that Cb- neurons comprise a functional heterogeneous population of border cells, band cells, head-direction cells and not spatially modulated cells. Because we did not obtain enough Cb+ cell recordings with sufficient spatial coverage, we cannot yet assess their spatial discharge patterns. Strikingly, while spike trains in only few (2 out of 13) of the Cb- neurons were theta modulated, most (3 out 4) Cb+ neurons were strongly theta modulated. This data was consistent with results obtained under urethane-anesthesia, where Cb+ cells were also more strongly entrained to theta rhythmicity. In summary, our preliminary results suggest that Cb+ neurons might represent a unique subpopulation of rhythmically discharging layer 2 neurons in vivo. We wonder if grid cells are recruited from this population, and we are currently testing this hypothesis.
publisher: ZDV Universität Tübingen
contributors: Bernstein Center for Computational Neuroscience Tübingen (BCCN) (producer), Bethge, Matthias (organizer), Wichmann, Felix (organizer), Lam, Judith (organizer), Macke, Jakob (organizer)
creation date: 2013-09-27
dc type: image
localtype: video
identifier: UT_20130927_004_bestcon_0001
language: eng
rights: Url: https://timmsstatic.uni-tuebingen.de/jtimms/TimmsDisclaimer.html?638499566563959482