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Decision-making under uncertainty: Probing the neural basis of mental models
Karpova, Alla; Brecht, Michael (2013)
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mla
clipboard		 Karpova A., et al. "Decision-making under uncertainty: Probing the neural basis of mental models.", timms video, Universität Tübingen (2013): https://timms.uni-tuebingen.de:443/tp/UT_20130927_006_bestcon_0001. Accessed 09 Mar 2025.
apa
clipboard		 Karpova, A. & Brecht, M. (2013). Decision-making under uncertainty: Probing the neural basis of mental models. timms video: Universität Tübingen. Retrieved March 09, 2025 from the World Wide Web https://timms.uni-tuebingen.de:443/tp/UT_20130927_006_bestcon_0001
harvard
clipboard		 Karpova, A. and Brecht, M. (2013). Decision-making under uncertainty: Probing the neural basis of mental models [Online video]. 27 September. Available at: https://timms.uni-tuebingen.de:443/tp/UT_20130927_006_bestcon_0001 (Accessed: 9 March 2025).
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title: Decision-making under uncertainty: Probing the neural basis of mental models
alt. title: Bernstein Conference 2013: Decision Making
creators: Karpova, Alla (author), Brecht, Michael (annotator)
subjects: Bernstein Conference, Computational Neuroscience, Decision Making, Uncertainty, Neural Basis, Mental Models, Alla Karpova
description: Bernstein Conference 2013, 24. bis 27. September 2013
abstract: The overall interest of my lab is to understand how model-based inference is accomplished by neural circuits. Over the past few years we have focused on the role that the rodent medial prefrontal cortex (mPFC), an area homologous to primate anterior cingulate cortex (ACC), plays in encoding the internal representation of the rules of the environment. We have designed behavioral tasks in which these rules change suddenly or evolve in a very complex mannerin some cases eliciting abrupt changes in the workings of the internal model and in others leading to the abandonment of attempts at model construction. Recordings of the activity of neuronal ensembles in mPFC revealed that moments of abrupt change in behavioral strategy are associated with sudden transitions in the pattern of neural activity across the mPFC, one interpretation of which is that such changes signify a reset of prior expectations. In addition, inactivation of mPFC by local muscimol administration revealed that the influence of mPFC on behavior is suppressed when attempts to build an internal model are unsuccessful. In combination, our observations argue that mPFC represents an animal's beliefs about the environment's governing rules.
publisher: ZDV Universität Tübingen
contributors: Bernstein Center for Computational Neuroscience Tübingen (BCCN) (producer), Bethge, Matthias (organizer), Wichmann, Felix (organizer), Lam, Judith (organizer), Macke, Jakob (organizer)
creation date: 2013-09-27
dc type: image
localtype: video
identifier: UT_20130927_006_bestcon_0001
language: eng
rights: Url: https://timmsstatic.uni-tuebingen.de/jtimms/TimmsDisclaimer.html?638770882125340071